| Metric | Q4'25 | Q1'26 | Change |
|---|---|---|---|
| Total Revenue | $700M (Q4 2025, down from $1.9B FY) | $400M (Q1 2026, up from $100M Q1 2025) | +300% YoY driven by international partnerships |
| International Revenue Mix | 57% ($400M of $700M Q4) | 80% ($320M of $400M Q1) | Geographic shift toward partnership revenues |
| Cost of Sales | $868M FY 2025 (41% decrease YoY) | $77M ex-settlement (Q1, 14% decrease YoY) | Underlying improvement excluding $878M Arbutus charge |
| R&D Expenses | $3.1B FY 2025 (31% decrease YoY) | $649M Q1 (24% decrease YoY) | Continued clinical wind-down, but Phase III programs advancing |
| SG&A Expenses | $1B FY 2025 (13% decrease YoY) | $173M Q1 (18% decrease YoY) | Cost discipline accelerating |
| Net Loss | $2.8B FY 2025 vs $3.6B FY 2024 | $500M ex-settlement Q1 (vs $1B Q1 2025) | 50%+ improvement in underlying losses |
| Cash and Investments | $8.1B end of 2025 | $7.5B end Q1 2026 | $600M decrease from operations, settlement not yet paid |
| Adjusted Cash Costs | $4.3B FY 2025 vs $5.5B guidance | $4.2B target for FY 2026 | 26% YoY reduction Q1, on track for full year |
| Revenue Growth Guidance | Up to 10% for 2026 (from Q4 call) | Reiterating up to 10% for 2026 | Maintained despite flu setback |
| Geographic Revenue Split Guidance | 50/50 US/International expected 2026 | 50/50 US/International maintained | Partnership revenues offsetting US market challenges |
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