| Metric | Q4'25 | Q1'26 | Change |
|---|---|---|---|
| Total Revenue | $18.0B (vs $13.1B Q4 2024, +37%) | $28.1B (vs $18.0B Q1 2025, +56%) | +1,900 bps acceleration in growth rate |
| Non-GAAP EPS | $7.54 (vs $5.32 Q4 2024) | $8.55 (vs $3.34 Q1 2025, +156%) | +3x earnings growth |
| Key Products Revenue | $14.3B combined (est) | >$21B combined | +$7B absolute growth from key products alone |
| Mounjaro + Zepbound Combined | $11.3B Q4 (est) | $12.8B | +$6.7B vs Q1 2025, but only +$1.5B sequential |
| International Mounjaro | $3.3B Q4 2025 | Not disclosed separately | Revenue disclosure granularity REDUCED |
| US Pricing Impact | -7% Q4 | -7% (or -10% ex-onetime adjustments) | Pricing pressure stabilized but onetime boost masks reality |
| R&D Expenses | 26% growth in 2025 | 28% growth Q1 | +200 bps acceleration in R&D spending |
| Performance Margin | 47.2% Q4 | 50% | +280 bps margin expansion |
| Foundayo Prescribers | 0 (pre-launch) | 8,000+ prescribers | 1/3 are new to oral GLP-1 class |
| Foundayo Patients | 0 | 20,000+ patients | 80% are new to class (expansionary) |
Get free previews of our earnings-call research: the key changes, management scores, and questions worth investigating. Subscribe for full call sheets and deeper analysis.
Subscriptions are managed by Substack. If the form does not load, subscribe directly. Or follow the RSS feed.