| Metric | Q3'25 | Q4'25 | Change |
|---|---|---|---|
| Total Revenue | $12.2B (flat YoY) | $12.5B (flat YoY) | Steady amid portfolio churn |
| Growth Portfolio Revenue | $6.4B (+17% YoY) | $7.4B (+15% YoY) | 200bp deceleration but still robust |
| Gross Margin | ~73% | 71.9% (-210bp) | Sharp compression from mix shift |
| Operating Expenses | $4.2B (-$100M YoY) | $16.3B (guidance, down YoY) | Cost discipline maintained |
| Eliquis Revenue | $3.7B (+23% YoY) | $3.5B (+6% YoY) | Growth deceleration before reacceleration |
| Opdivo Revenue | $2.5B (+6% YoY) | $2.7B (+7% YoY) | Modest acceleration |
| Reblozyl Revenue | $615M (strong growth) | Over $2B annualized (+21% Q4) | Crossed $2B threshold |
| Breyanzi Revenue | $359M (+58% YoY) | Over $1B annualized (+47% Q4) | Crossed $1B threshold |
| Camzyos Revenue | $296M (+88% YoY) | $353M (+57% Q4) | Growth moderating but strong |
| CoBinfy Revenue | $43M Q3 | $51M Q4 | Sequential growth but decelerating |
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